TRK fusion proteins: oncogenic drivers in a variety of tumors across adult and pediatric cancers

TRK fusion proteins are oncogenic drivers that occur in a broad range of tumor types with varying frequency and across both pediatric and adult patients.1,2

Estimated frequency of NTRK gene fusion in specific tumor types

TRK fusion proteins

 

Frequencies reported from isolated studies that used variable methodologies to detect these genetic alterations.

a Papillary thyroid carcinoma.2,5
b Lung adenocarcinoma that did not contain other common oncogenic alterations.2,7

 

References: 1. Amatu A, Sartore-Bianchi A, Siena S. NTRK gene fusions as novel targets of cancer therapy across multiple tumour types. ESMO Open. 2016;1(2):e000023. 2. Stransky N, Cerami E, Schalm S, Kim JL, Lengauer C. The landscape of kinase fusions in cancer. Nat Commun. 2014;5:4846. doi:10.1038/ncomms5846. 3. Bourgeois JM, Knezevich SR, Mathers JA, Sorensen PHB. Molecular detection of the ETV6-NTRK3 gene fusion differentiates congenital fibrosarcoma from other childhood spindle cell tumors. Am J Surg Pathol. 2000;24(7):937-946. 4. Rubin BP, Chen C-J, Morgan TW, et al. Congenital mesoblastic nephroma t(12;15) is associated with ETV6-NTRK3 gene fusion. Am J Pathol. 1998;153(5):1451-1458. 5. Brzeziańska E, Karbownik M, Migdalska-Sęk M, Pastuszak-Lewandoska D, Włoch J, Lewiński A. Molecular analysis of the RET and NTRK1 gene rearrangements in papillary thyroid carcinoma in the Polish population. Mutat Res. 2006;599(1-2):26-35. 6. Wu G, Diaz AK, Paugh BS, et al. The genomic landscape of diffuse intrinsic pontine glioma and pediatric non-brainstem high-grade glioma. Nat Genet. 2014;46(5):444-450. 7. Vaishnavi A, Capeletti M, Le AT. Oncogenic and drug sensitive NTRK1 rearrangements in lung cancer. Nat Med. 2013;19(11):1469-1472. 8. Kim J, Lee Y, Cho H-J, et al. NTRK1 fusion in glioblastoma multiforme. PLoS One. 2014;19;9(3):e91940. doi:10.1371/journal.pone.0091940.

 

 

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